Seth Rhoades

Postdoctoral Fellow
Google Scholar

I joined the Vanderbilt Department of Biomedical Informatics as a postdoc in September 2017. My primary interests are in sequential modeling of medical data for both sleep and circadian applications and generalizable clinical decision support enabled by a better understanding of disease progression and effective interventions.

I began my research endeavors as an undergraduate at Wake Forest University, where I studied the influence of insect hormones on neuron growth in regions of the honeybee brain related to olfactory memory. Although I didn’t work on honeybees for long, this experience gave me a passion for research and so I set out to obtain a PhD in pharmacology.

Little did I know that my PhD research at the University of Pennsylvania would not take me far from honeybees, as I ended up working on fruit flies. During my time in the lab of Aalim Weljie, I focused on developing mass spectrometry-based methods to quantify and understand circadian rhythms in global metabolism. I developed a way to measure metabolic dynamics in vivo through the incorporation of isotope tracers, and analogously developed an approach to simulate the flow of isotopically-labeled atoms through metabolic networks. Through all this, I gained an appreciation for the difficulties of interpreting high-dimensional omics data.

I departed the Hughey Lab in August 2018 to pursue my goal of a startup based on in silico drug discovery.

Outgoing haiku

Snake sleep cycles rhyde
Zeit gegeben unit tests
Awake my growthWAS


Pulling the covers in electronic health records for an association study with self-reported sleep behaviors, Rhoades et al., Chronobiol Int 2018